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As with other GLP-1 medicines, people with: A history of severe gastrointestinal disease Pancreatitis Significant kidney or liver issues should only use GLP-1 treatments under close clinical monitoring
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The FDA label includes a boxed warning regarding thyroid C-cell tumors observed in rodent studies, though the relevance to humans remains uncertain
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It minimizes the action of the GLP-1 hormone, which controls appetite and insulin secretion
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